In an episode directed by Hugh Laurie, the team takes on the case of a six-year-old (guest star Rachel Eggleston) with numerous pre-existing health problems. They soon realize they must work with the girl’s mother, Elizabeth (guest star Jessica Collins), a doctor who specializes in her daughter’s genetic condition. But while searching the family’s home for clues, the team discovers that Elizabeth’s determination to cure her daughter could be the very thing that is killing her. Also, House and Wilson take a little vacation.
May 7: “Post Mortem”
In an episode directed by and guest-starring Peter Weller (Dexter, RoboCop), the team takes on the case of Dr. Peter Treiber (guest star Jamie Elman), a pathologist at Princeton-Plainsboro Teaching Hospital who knows too much about the hospital staff to trust any of the physicians. The only person he does respect is House, who has mysteriously gone missing. With House in absentia, the team has to figure out how to treat Treiber while making him believe that House is calling all the shots.
May 14: “Holding On”
Former Princeton Plainsboro colleague Thirteen (Olivia Wilde) returns in an all-new episode. The team takes on the case of Derrick (guest star Skylar Astin), a 19-year-old college student who had a mysterious nose bleed during cheerleading practice, and discovers that his health issues are likely both physiological and psychological. Possibly suffering from schizophrenia, Derrick claims to hear his deceased brother’s voice in his head. Meanwhile, Foreman tries a different approach with House.
May 21: “Everybody Dies” (Series Finale)
In the emotional series finale, which is preceded by an hour-long retrospective, treating a drug addict patient (guest star James Legros) results in House examining his life, his future and his own personal demons.